Modelled supplements for Amyotrophic lateral sclerosis (ALS) Motor Neuron

Conventional Beliefs

  1. Antioxidants: Antioxidants such as vitamins C and E have been investigated for their potential to reduce oxidative stress, which is implicated in the progression of ALS. While research has not conclusively shown their effectiveness in slowing ALS progression, maintaining adequate levels of antioxidants through diet or supplements might be beneficial for overall health.

  2. Omega-3 Fatty Acids: Omega-3 fatty acids found in fish oil or certain plant sources possess anti-inflammatory properties. Some studies suggest that omega-3 supplementation might have a potential role in reducing inflammation and oxidative stress, which could be beneficial for individuals with ALS. However, evidence supporting their efficacy is limited.

  3. Vitamin D: Vitamin D deficiency has been associated with a higher risk of ALS. Some studies suggest that maintaining adequate vitamin D levels might have a neuroprotective effect and could potentially influence the risk or progression of ALS. However, more research is needed to establish a clear link.

  4. Probiotics: The gut microbiota's influence on overall health, including neurological conditions, has prompted research into the potential role of probiotics in ALS. While the exact mechanisms are not fully understood, maintaining a healthy gut microbiota through probiotics might have indirect effects on overall health. However, direct evidence linking probiotics to ALS prevention or treatment is lacking.

For an explanation of how this is generated, see this post

All suggestions from this page should be reviewed by your medical professionals. These are based on modelling and not clinical studies.

Based on family and lower taxonomy ranks (genus,species,strains) reported in studies, the list is here

Net Impact Modifier Citations
27 inulin (prebiotic)   📏🍽️ Dosages 📚
23.2 vitamin d   📏🍽️ Dosages 📚
20.6 fructo-oligosaccharides (prebiotic)   📏🍽️ Dosages 📚
20.3 Human milk oligosaccharides (prebiotic, Holigos, Stachyose)   📏🍽️ Dosages 📚
19.3 resveratrol (grape seed/polyphenols/red wine)   📏🍽️ Dosages 📚
17.8 soy   📏🍽️ Dosages 📚
16.9 arabinogalactan (prebiotic)   📏🍽️ Dosages 📚
15.2 wheat bran   📚
11.4 lactobacillus plantarum (probiotics)   📏🍽️ Dosages 📚
11 wheat   📚
10.7 pomegranate   📏🍽️ Dosages 📚
10.5 Conjugated Linoleic Acid   📚
10.4 Cacao   📏🍽️ Dosages 📚
10.3 oligosaccharides (prebiotic)   📚
10.3 Dangshen   📚
9.5 bacillus subtilis (probiotics)   📏🍽️ Dosages 📚
9 bifidobacterium longum (probiotics)   📏🍽️ Dosages 📚
9 mediterranean diet   📚
8.9 Limosilactobacillus fermentum (probiotic)   📏🍽️ Dosages 📚
8.9 Moringa Oleifera   📚
8.8 fasting   📚
8.6 Apigenin   📚
8.3 Lactobacillus Johnsonii (probiotic)   📏🍽️ Dosages 📚
7.9 banana   📚
7.9 lactobacillus casei (probiotics)   📏🍽️ Dosages 📚
7.9 Slippery Elm   📚
7.8 Glucomannan   📏🍽️ Dosages 📚
7.7 apple   📚
7.6 ketogenic diet   📚
7.4 gum arabic (prebiotic)   📏🍽️ Dosages 📚
7.1 berberine   📏🍽️ Dosages 📚
6.9 Ursolic acid   📚
6.7 lactobacillus plantarum,xylooligosaccharides,(prebiotic) (probiotics)   📚
6.6 barley,oat   📚
6.5 lactobacillus rhamnosus (probiotics)   📏🍽️ Dosages 📚
6.5 whey   📏🍽️ Dosages 📚
6.5 Astragalus   📚
6.3 lactobacillus acidophilus (probiotics)   📏🍽️ Dosages 📚
6.2 lactobacillus sakei (probiotics)   📚
6.1 barley   📏🍽️ Dosages 📚
6 l-proline   📚
5.9 jerusalem artichoke (prebiotic)   📏🍽️ Dosages 📚
5.9 Soymilk   📚
5.9 pectin   📚
5.7 quercetin   📏🍽️ Dosages 📚
5.7 omega-3 fatty acids   📏🍽️ Dosages 📚
5.6 garlic (allium sativum)   📏🍽️ Dosages 📚
5.6 black raspberries   📏🍽️ Dosages 📚
5.5 vitamin b2,Riboflavin   📏🍽️ Dosages 📚
5.5 Shen Ling Bai Zhu San   📚
5.3 Vitamin C (ascorbic acid)   📏🍽️ Dosages 📚
5.2 aspergillus oryzae   📚
5.1 fat   📚
5.1 bifidobacterium animalis lactis (probiotics)   📏🍽️ Dosages 📚
5.1 vitamin a   📏🍽️ Dosages 📚
5 vegetarians   📚
4.9 partially hydrolysed guar gum,fructo-oligosaccharides (prebiotic)   📚
4.9 bifidobacterium lactis bb12 (probiotics)   📏🍽️ Dosages 📚
4.9 lactobacillus paracasei (probiotics)   📏🍽️ Dosages 📚
4.8 oolong teas   📚
4.8 purple sweet potatoes   📚
4.7 Bromelain   📏🍽️ Dosages 📚
4.6 blueberry   📚
4.6 vegetable/fruit juice-based diets   📚
4.5 xylooligosaccharide (prebiotic)   📏🍽️ Dosages 📚
4.5 pea (fiber, protein)   📚
4.5 Rutin   📏🍽️ Dosages 📚
4.4 zinc   📏🍽️ Dosages 📚
4.3 persimmon tannin   📚
4.3 fish oil   📏🍽️ Dosages 📚
4.1 cranberry bean flour   📚
4.1 lupin seeds (anaphylaxis risk, toxic if not prepared properly)   📚
4.1 Pistachio   📚
4 galacto-oligosaccharides (prebiotic)   📏🍽️ Dosages 📚
4 mulberry fruit polysaccharide   📚
4 mannooligosaccharide (prebiotic)   📏🍽️ Dosages 📚
3.9 GABA   📏🍽️ Dosages 📚
3.9 Sodium alginate   📏🍽️ Dosages 📚
3.8 Alpha-Ketoglutarate   📚
3.8 xylan (prebiotic)   📚
3.8 whole grain,bran   📚
3.7 bifidobacterium pseudocatenulatum,(probiotics)   📚
3.7 bioflorin,enterococcus faecium sf 68,(probiotics)   📚
3.7 glycine   📏🍽️ Dosages 📚
3.6 Pulses   📚
3.6 grape polyphenols   📚
3.5 enterococcus faecium (probiotic)   📏🍽️ Dosages 📚
3.5 ku ding cha tea   📚
3.5 oregano (origanum vulgare, oil) |   📚
3.5 Ginseng   📏🍽️ Dosages 📚
3.5 gluten   📚
3.5 Pumpkin   📚
3.4 Manjistha (Rubia cordifolia)   📚
3.4 Burdock Root   📚
3.4 corn   📚
3.4 genistein   📚
3.3 almonds/ almond skins   📏🍽️ Dosages 📚
3.2 animal-based diet   📚
3.2 high fiber diet   📚
3.2 sesame cake/meal   📚
3.1 grape seed extract   📏🍽️ Dosages 📚
3.1 bifidobacterium catenulatum,(probiotics)   📚
3.1 pediococcus acidilactic (probiotic)   📚
3 Goji (berry,juice)   📚
3 bifidobacterium bifidum (probiotics)   📏🍽️ Dosages 📚
3 lactobacillus reuteri (probiotics)   📏🍽️ Dosages 📚
3 l-glutamine   📏🍽️ Dosages 📚
3 emblica officinalis   📚
2.9 lactobacillus rhamnosus gg (probiotics)   📏🍽️ Dosages 📚
2.9 green tea   📚
2.9 Kiwifruit   📚
2.8 Codonopsis pilosula   📚
2.8 grape fiber   📚
2.8 Kaempferol   📚
2.7 Citrus Fruit Extract   📚
2.7 fenugreek   📚
2.7 high-fat sucrose   📚
2.7 white button mushrooms   📚
2.7 cinnamon (oil. spice)   📏🍽️ Dosages 📚
2.7 melatonin supplement   📏🍽️ Dosages 📚
2.7 safflower oil   📚
2.6 palm kernel meal   📚
2.6 fibre-rich macrobiotic ma-pi 2 diet   📚
2.6 ginger   📚
2.6 oolong tea polyphenols   📚
2.6 fruit/legume fibre   📚
2.6 plantago asiatica l.   📚
2.6 Exercise   📚
2.5 rye   📚
2.5 rhubarb   📚
2.5 Far infrared Sauna   📚
2.4 noni   📏🍽️ Dosages 📚
2.3 Bofutsushosan   📚
2.3 vsl#3 (probiotics)   📚
2.3 dietary phytoestrogens (isoflavones)   📚
2.2 mannitol   📚
2.2 sesame   📚
2.2 Gluco-Oligosaccharides   📚
2.2 amaranth   📚
2.2 trametes versicolor(Turkey tail mushroom)   📚
2.2 triphala   📏🍽️ Dosages 📚
2.2 glutamate   📚
2.2 grapes   📚
2.2 partially hydrolyzed guar gum   📏🍽️ Dosages 📚
2.1 camellia   📚
2.1 Vitamin E   📏🍽️ Dosages 📚
2.1 Onion   📚
2.1 low protein diet   📚
2 bacillus amyloliquefaciens (probiotic)   📏🍽️ Dosages 📚
2 spirulina(cyanobacteria)   📚
2 oats   📚
2 Tryptophan   📏🍽️ Dosages 📚
1.9 lactobacillus casei shirota (probiotics)   📏🍽️ Dosages 📚
1.9 Akkermansia muciniphila (probiotic)   📏🍽️ Dosages 📚
1.9 hou-po-da-huang-tang   📚
1.9 yogurt   📚
1.9 brown algae   📚
1.9 green-lipped mussel   📚
1.9 whole-grain barley   📏🍽️ Dosages 📚
1.9 oligofructose-enriched inulin (prebiotic)   📚
1.8 buckwheat   📚
1.8 propionate   📚
1.8 Caffeine   📚
1.8 glycyrrhizic acid (licorice)   📏🍽️ Dosages 📚
1.7 dietary fiber   📚
1.7 high amylose cornstarch   📚
1.7 Goat milk   📚
1.6 Papain   📚
1.6 rosmarinus officinalis,rosemary   📚
1.6 blackcurrant   📚
1.6 germinated barley food-stuff   📚
1.6 Whole Cow milk   📚
1.6 bifidobacterium infantis,(probiotics)   📏🍽️ Dosages 📚
1.6 l-sorbose   📚
1.6 lactobacillus salivarius (probiotics)   📏🍽️ Dosages 📚
1.6 resistant maltodextrin   📏🍽️ Dosages 📚
1.6 red wine   📏🍽️ Dosages 📚
1.5 Guaiacol (polyphenol)   📚
1.5 magnesium   📏🍽️ Dosages 📚
1.5 l-taurine   📏🍽️ Dosages 📚
1.5 acetic acid   📚
1.5 wormwood(artemisia)   📚
1.5 chondrus crispus,red sea weed   📚
1.5 sarcodiotheca gaudichaudii (red sea weed)   📚
1.5 quercetin,resveratrol   📚
1.4 high red meat   📚
1.4 carob   📚
1.4 lactobacillus brevis (probiotics)   📏🍽️ Dosages 📚
1.4 low carbohydrate diet   📚
1.3 slow digestible carbohydrates   📚
1.3 broccoli   📚
1.3 high resistant starch   📚
1.3 bacillus,lactobacillus,streptococcus,saccharomyces probiotic   📚
1.3 fucoidan   📏🍽️ Dosages 📚
1.2 punicic acid   📚
1.2 Theanine   📚
1.2 Bifidobacterium animalis   📚
1.2 wasabi   📚
1.2 Sauerkraut   📚
1.2 Beet   📚
1.2 Fucose   📚
1.2 maize   📚
1.2 bean   📚
1.2 linseed(flaxseed)   📏🍽️ Dosages 📚
1.2 dates   📚
1.2 sodium butyrate   📚
1.2 plantain bananas   📚
1.2 navy bean   📚
1.1 lard   📚
1.1 resistant starch   📚
1.1 bacillus subtilis natto (probiotics)   📚
1.1 whole-grain wheat   📚
1.1 clostridium butyricum (probiotics),Miya,Miyarisan   📏🍽️ Dosages 📚
1.1 bifidobacterium breve (probiotic)   📏🍽️ Dosages 📚
1.1 Cinnamaldehyde   📚
1.1 Glucosamine   📚
1.1 chlorine   📚
1 Xanthan gum   📚
1 carrageenan   📚
1 Olive Oil   📚
1 Krill Oil   📏🍽️ Dosages 📚
1 Turmeric   📏🍽️ Dosages 📚
1 Rhodiola rosea (Rosavin)   📏🍽️ Dosages 📚
1 quinoa   📚
1 western diet   📚
1 Artemisinin   📚
1 bacillus (probiotics)   📚
1 chicory (prebiotic)   📏🍽️ Dosages 📚
1 l-arginine   📏🍽️ Dosages 📚
1 polyphenols   📏🍽️ Dosages 📚
1 schisandra chinensis(magnolia berry or five-flavor-fruit)   📚
1 sunflower oil   📚
0.9 Pineapple   📚
0.9 Miso   📚
0.9 lactobacillus rhamnosus gg,lactobacillus,rhamnosus,propionibacterium freudenreichii,bifidobacterium breve (probiotics)   📚
0.9 Baicalin   📚
0.9 Xanthohumol   📚
0.8 Ferric citrate   📚
0.8 avocado peel   📚
0.8 lupin kernel fiber (legume) (anaphylaxis risk, toxic if not prepared properly)   📚
0.8 saccharomyces boulardii (probiotics)   📏🍽️ Dosages 📚
0.8 low-fat high-complex carbohydrate diet   📚
0.8 lactobacillus gasseri (probiotics)   📏🍽️ Dosages 📚
0.7 hypocaloric hyperproteic diet   📚
0.7 low fodmap diet   📚
0.7 Perilla frutescens(shiso)   📏🍽️ Dosages 📚
0.7 enterococcus durans (probiotics)   📚
0.7 bacillus coagulans (probiotics)   📏🍽️ Dosages 📚
0.7 bifidobacterium adolescentis,(probiotics)   📏🍽️ Dosages 📚
0.7 nigella sativa seed (black cumin)   📏🍽️ Dosages 📚
0.7 symbioflor 2 e.coli probiotics   📚
0.7 hydrogenated palm oil   📚
0.6 Sijunzi decoction   📚
0.6 Lentilactobacillus buchneri   📚
0.6 marijuana   📚
0.6 bifidobacterium longum bb536 (probiotics)   📚
0.6 vitamin B7, biotin   📏🍽️ Dosages 📚
0.6 Bell Pepper   📚
0.6 Pterostilbene   📚
0.6 Lithium   📚
0.6 Oyster Mushroom   📚
0.5 rice bran   📚
0.5 Methionine   📏🍽️ Dosages 📚
0.5 potatoes   📚
-0.5 Grapefruit seed extract   📚
-0.5 schinus molle (herb)   📚
-0.5 Cheese   📚
-0.6 Fisetin   📏🍽️ Dosages 📚
-0.6 colostrum   📚
-0.6 cruciferous vegetables (broccoli cabbage)   📚
-0.6 retinoic acid,(Vitamin A derivative)   📚
-0.6 cherry   📚
-0.6 starch-fed   📚
-0.6 Pediococcus pentosaceus   📚
-0.6 Apple skin   📚
-0.6 Prescript Assist (2018 Formula)   📚
-0.6 lactobacillus helveticus,lactobacillus rhamnosus (probiotics)   📚
-0.7 peppermint (spice, oil)   📚
-0.7 red wine polyphenols   📏🍽️ Dosages 📚
-0.7 enriched butter diet   📚
-0.7 cvs maximum strength probiotic   📚
-0.7 chicken   📚
-0.7 diosmin,(polyphenol)   📏🍽️ Dosages 📚
-0.7 alcoholic beverages   📚
-0.8 whole grain diet   📚
-0.8 Konjaku flour   📚
-0.8 extra virgin olive oil   📚
-0.8 coriander oil   📚
-0.8 lactobacillus kefiri (NOT KEFIR)   📚
-0.9 ß-glucan   📏🍽️ Dosages 📚
-0.9 chaga (mushroom)   📚
-0.9 ethanol   📚
-0.9 annatto   📚
-0.9 PreforPro   📚
-0.9 bacillus laterosporus (probiotic)   📚
-1 rice   📚
-1 high-saturated fat diet   📚
-1 capsaicin (hot pepper)   📚
-1 lacto-ovo-vegetarian diet   📚
-1.1 tannic acid   📚
-1.1 doenjang (fermented bean paste)   📚
-1.1 Hesperidin (polyphenol)   📏🍽️ Dosages 📚
-1.1 Umeboshi (Japanese Apricot or Prunus mume )   📚
-1.1 Mangosteen   📚
-1.1 red alga Laurencia tristicha   📚
-1.1 Dendrobium officinale   📚
-1.2 low-fat diets   📚
-1.2 fraxinus angustifolia,narrow-leafed ash   📚
-1.2 choline   📏🍽️ Dosages 📚
-1.3 chitooligosaccharides (prebiotic)   📏🍽️ Dosages 📚
-1.3 Nicotine, Nicotine Patch   📚
-1.3 trachyspermum ammi, Ajwain   📚
-1.3 Sumac(Rhus coriaria)   📚
-1.4 Leonurine   📚
-1.4 Carthamus tinctorius L,Safflower   📚
-1.4 camelina seed   📚
-1.4 syzygium aromaticum (clove)   📚
-1.4 mastic gum (prebiotic)   📏🍽️ Dosages 📚
-1.4 neem   📏🍽️ Dosages 📚
-1.5 mutaflor escherichia coli nissle 1917 (probiotics)   📏🍽️ Dosages 📚
-1.5 high beef diet   📚
-1.6 fruit   📚
-1.6 dairy   📚
-1.6 Sulforaphane,1-Isothiocyanato-4-(methanesulfinyl)butane,C6H11NOS2   📚
-1.7 polygonatum kingianum(Orange Flower Solomon's Seal.)   📚
-1.7 salt (sodium chloride)   📚
-1.7 Rhubarb Peony Decoction   📚
-1.8 high sugar diet   📚
-1.8 Dextrin   📏🍽️ Dosages 📚
-1.9 quebracho   📚
-1.9 candida albicans (prescription)   📚
-1.9 Fish   📚
-1.9 Psyllium (Plantago Ovata Husk)   📏🍽️ Dosages 📚
-2 walnuts   📏🍽️ Dosages 📚
-2.2 sorghum   📚
-2.2 Tudca   📏🍽️ Dosages 📚
-2.3 Coenzyme Q10   📏🍽️ Dosages 📚
-2.3 galla chinensis (herb)   📚
-2.3 brassica juncea   📚
-2.3 high-protein diet   📚
-2.8 Curcumin   📏🍽️ Dosages 📚
-2.8 Pork   📚
-2.8 rare meat   📚
-2.9 refined wheat breads   📚
-2.9 Boron (Organic Source)   📚
-3 fluorine   📚
-3 bifidobacterium pseudocatenulatum li09,bifidobacterium catenulatum li10 (probiotics)   📚
-3.3 brown rice   📚
-3.8 Vitamin B1,thiamine hydrochloride   📏🍽️ Dosages 📚
-4.9 gluten-free diet   📚
-14 high-fat diets   📚

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